Dr. Parisa Asghari with Dr. Edwin Moore in Dept of Cellular and Physiological Sciences study the structure/function relationship of cardiac calcium channel, type II Ryanodine Receptors in health and disease. The transmission electron micrograph on the left shows a cross-section of a dyad in a normal rat ventricular myocyte, T-tubule membrane traced in green, Junctional Sarcoplasmic Reticulum in blue and Type II Ryanodine Receptors in pink. She used FEI Tecnai TEM to perform Electron Tomography to investigate the distribution of ryanodine receptors on the surface of junctional sarcoplasmic reticulum adjacent to T-tubules. AMIRA software used for reconstruction and segmentation of the 3D models (right).